Creating hemoglobin blood substitute (PNPH) with nitric oxide catalytic activity as antioxidants, anti-inflammation and immune-modulation therapeutic drugs for treatment of global unmet medical needs and healthcare including stroke, cancer, trauma, Alzheimer’s Disease, sickle cell disease and glioplastoma are described.

The neuroprotective drug PNPH is up to 50 times more effective than whole blood and can be packaged in less than 50cc for the therapeutic application of five unmet medical needs.