Publications
Treatment of major medical conditions using AntiRadical's drug pipeline
1: Soltys BJ, Grausam KB, Messerli SM, Hsia CJC and Zhao H (2023) Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles. Frontiers in Oncology. 13:1129533. doi: 10.3389/fonc.2023.1129533
2: Wang J, Shi Y, Cao S, Liu X, Martin LJ, Simoni J, Soltys BJ, Hsia CJC and Koehler RC (2023) Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock. Frontiers in Medical Technology. 5:1074643. doi: 10.3389/fmedt.2023.1074643
3: Day, W.G., Soltys, B.J., Cole, J., Simoni, J., Hsia, C.J.C., Lin, A.H. (2022). Potential Value of Polynitroxylated PEGylated Hemoglobin (SanFlow) in Pre-Hospital Medicine in Austere Environments including Military Deployments, Disasters and Remote Emergencies. In: Liu, H., Kaye, A.D., Jahr, J.S. (eds) Blood Substitutes and Oxygen Biotherapeutics. 2022. Springer, Cham.https://doi.org/10.1007/978-3-030-95975-3_23
4: Seno S, Wang J, Cao S, et al., Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock. BMC Neurosci. 2020;21(1):22. doi: 10.1186/s12868-020-00571-7. PMID: 32404052
5: Hsia CJC, et al. Can Anti-Metastatic Albumin-based Superoxide Dismutase Mimetic Serve as a "Moonshot" Drug for Treatment for Brain Tumors - From Medulloblastoma to Glioblastoma? Cell Biochem Biophys. 2019 Jun;77(2):121-122. doi: 10.1007/s12013-019-00869-2. Epub 2019 May 15. PubMed PMID: 31093886.
6: Messerli SM, et al. Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer. J Oncol. 2019 Feb 28;2019:3253696. doi:10.1155/2019/3253696. eCollection 2019. PubMed PMID: 30941174; PubMed Central PMCID: PMC6420975.
7: Hsia CJC, Miskimins WK. Can Macromolecular Nitroxide Work as Extracellular Superoxide Dismutase Mimetic in Cancer and Stroke Therapy? Cell Biochem Biophys. 2018 Dec;76(4):443-444. doi: 10.1007/s12013-018-0853-6. Epub 2018 Sep 6. PubMed PMID: 30191451.
8: Cao S, et al. Transfusion of Polynitroxylated Pegylated Hemoglobin Stabilizes Pial Arterial Dilation and Decreases Infarct Volume After Transient Middle Cerebral Artery Occlusion. J Am Heart Assoc. 2017 Sep 12;6(9). pii: e006505. doi: 10.1161/JAHA.117.006505. PubMed PMID: 28899897; PubMed Central PMCID: PMC5634295.
9: Brockman EC, et al Polynitroxylated Pegylated Hemoglobin-A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation. J Neurotrauma. 2017 Apr 1;34(7):1337-1350. doi: 10.1089/neu.2016.4656. Epub 2017 Jan 13. PubMed PMID: 27869558; PubMed Central PMCID: PMC5385578.
10: Byrd C, Wallisch J, Jha R, Vagni V, Wisniewski S, Ma L, Hsia C, Kochanek PM. Polynitroxylated-pegylated hemoglobin as an ultra-small volume resuscitation therapy. Critical Care Medicine. 2015;43(12):3-4.
11: Hsia CJ. Fast track approval of therapeutic blood substitutes. Artif Organs. 2014 Mar;38(3):179-81. doi: 10.1111/aor.12281. PubMed PMID: 24606130.
12: Brockman EC, et al. Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice. J Cereb Blood Flow Metab. 2013 Sep;33(9):1457-64. doi: 10.1038/jcbfm.2013.104. Epub 2013 Jun 26. PubMed PMID: 23801241; PubMed Central PMCID: PMC3764379.
13: Manole MD, et al. Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome. J Cereb Blood Flow Metab. 2012 Mar;32(3):560-9. doi:10.1038/jcbfm.2011.165. Epub 2011 Nov 30. PubMed PMID: 22126915; PubMed Central PMCID: PMC3293121.
14: Hsia CJ, Ma L. A hemoglobin-based multifunctional therapeutic: polynitroxylated pegylated hemoglobin. Artif Organs. 2012 Feb;36(2):215-20. doi: 10.1111/j.1525-1594.2011.01307.x. Epub 2011 Sep 28. PubMed PMID: 21955160; PubMed Central PMCID: PMC3653627.
15: Shellington DK, et al. Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice. Crit Care Med. 2011 Mar;39(3):494-505. PubMed PMID: 21169820; PubMed Central PMCID: PMC3425360. doi: 10.1097/CCM.0b013e318206b1fa.
16: Stoyanovsky DA, Kapralov A, Huang Z, Maeda A, Osipov A, Hsia CJ, Ma L, Kochanek PM, Bayr H, Kagan VE. Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H(2)O(2) coupled with intramolecular oxidation of nitroxides. Biochem Biophys Res Commun. 2010 Aug 20;399(2):139-43. doi: 10.1016/j.bbrc.2010.07.030. Epub 2010 Jul 17. PMID: 20643098
17: Exo JL, et al. Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: Effects on acute hemodynamics, survival, and neuronal death in mice. J Neurotrauma. 2009 Dec;26(12):2403-8. doi: 10.1089/neu.2009.0980. PubMed PMID: 19691424; PubMed Central PMCID: PMC2864460. doi: 10.1089/neu.2009.0980.
18: Kaul DK, et al. Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants. Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H167-75. Epub 2006 Jan 27. PubMed PMID: 16443674. doi: 10.1152/ajpheart.01096.2005.
19: Mahaseth H, et al. Polynitroxyl albumin inhibits inflammation and vasoocclusion in transgenic sickle mice. J Lab Clin Med. 2005 Apr;145(4):204-11. PubMed PMID: 15962839. doi: 10.1016/j.lab.2005.02.008.
20: Li H, Ma L, Hsia CJ, Zweier JL, Kuppusamy P. Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect of tempol in rat hearts subjected to regional ischemia-reperfusion. Free Radic Biol Med. 2002;32(8):712-9. PubMed PMID: 11937297. doi: 10.1016/s0891-5849(02)00762-1.
21: Sugawara T, Yu F, Ma L, Hsia CJ, Chan PH. Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats. Neuroreport. 2001;12(16):3609-12. PubMed PMID: 11733721. doi: 10.1097/00001756-200111160-00047.
22: Blonder JM, McCalden TA, Hsia CJ, Billings RE. Polynitroxyl albumin plus tempol attenuates liver injury and inflammation after hepatic ischemia and reperfusion. Life Sci. 2000;67(26):3231-9. PubMed PMID: 11191630. doi: 10.1016/s0024-3205(00)00907-3.
23: Saetzler 1, K E Arfors, R F Tuma, U Vasthare, L Ma, C J Hsia, H A Lehr. Polynitroxylated Hemoglobin-Based Oxygen Carrier: Inhibition of Free Radical-Induced Microcirculatory Dysfunction. Free Radic Biol Med. 1999 Jul;27(1-2):1-6. PMID: 10443913 DOI: 10.1016/s0891-5849(99)00037-4
24: Beaulieu C, Busch E, Rother J, de Crespigny A, Hsia CJ, Moseley ME. Polynitroxyl albumin reduces infarct size in transient focal cerebral ischemia in the rat: potential mechanisms studied by magnetic resonance imaging. J Cereb Blood Flow Metab. 1998;18(9):1022-31. doi: 10.1097/00004647-199809000-00012. PubMed PMID: 9740106.